May 28, 2024

Previously, METHYLPREDNISOLONE (Depo-Medrol R) was produced by several manufacturers, who have since left the market, leaving Pfizer as the sole supplier. Distributed by McKesson in Ontario, a shortage of the DM80mg/cc formulation was announced in March 2024.

This shortage was triggered by a label change rather than a manufacturing issue and has now been resolved.

IMPORTANT: McKesson has changed their unique product number (not the DIN) for the re-labelled 80mg/cc formulation from Pfizer. If you try to order using the old McKesson product number (927095), it may appear as ‚Äėdiscontinued‚ÄĚ; the new unique McKesson # 190333, should be used at this time.

Depo-Medrol 40 mg/cc formulation is undergoing a similar label change and will show as ‚Äúdiscontinued‚ÄĚ if ordering with the old McKesson product number, on or after the middle of June; we will provide the new product order number when it is available

Ensure that the new unique product numbers are used when ordering both the 40 mg and 80 mg Depo-Medrol via McKesson in Ontario.

At this time, we believe this product number change may only apply to Ontario. If you have or have had, a similar experience in provinces other than Ontario, please let us know by emailing