Canadian Rheumatology Association Position Statement on PDE5 inhibitors for the treatment of severe Raynaud’s Phenomenon

Patients with autoimmune diseases such as systemic sclerosis (scleroderma) often have severe Raynaud’s phenomenon (RP) which may or may not be associated with digital ulcers. There are other diseases that may have severe RP as a manifestation such as but not limited to: systemic lupus erythematosus (SLE), Sjogren’s disease, inflammatory myositis, vasculitis, inflammatory arthritis, and thromboangiitis obliterans...